Steam-in-Place (SIP) sterilization is a critical process in the pharmaceutical industry to ensure the sterility of permanently installed systems such as tanks, pipelines, and bioreactors in aseptic manufacturing. This process uses saturated steam to kill microorganisms without requiring the disassembly of equipment. The same standards and regulations applied to steam autoclaves/steam sterilizers are used in SIP. Relevant standards for moist heat sterilization, such as EN 285 or ISO 17665, are considered. Typically, the CIP (Clean-In-Place) process precedes the SIP process, preparing the equipment for sterilization.